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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
21.52
Human Site:
S185
Identified Species:
31.56
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
S185
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
R
Chimpanzee
Pan troglodytes
XP_520198
559
62217
S222
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
R
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
S184
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
R
Dog
Lupus familis
XP_532038
521
58332
S184
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
S184
R
L
W
I
A
N
Y
S
L
P
R
A
M
K
R
Rat
Rattus norvegicus
Q5BK30
415
45841
L88
N
F
Y
L
F
K
V
L
R
A
H
I
L
P
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
E63
R
A
M
K
R
L
E
E
A
R
L
H
K
E
I
Chicken
Gallus gallus
Q5ZMA2
505
55116
I172
L
A
G
M
T
P
E
I
I
Q
K
P
Q
D
K
Frog
Xenopus laevis
Q5FWQ6
415
45899
L88
Q
F
Y
L
F
K
V
L
R
A
H
I
L
P
L
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
L88
K
F
Y
L
F
R
A
L
Q
A
H
I
L
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
A83
E
K
E
V
I
E
G
A
P
T
K
N
K
R
T
Honey Bee
Apis mellifera
XP_393186
525
59172
S178
R
S
W
I
A
T
Y
S
L
P
R
A
K
A
R
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
K165
L
S
E
A
I
L
A
K
L
E
E
K
S
K
S
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
D170
E
Y
S
L
P
R
A
D
K
R
L
D
E
A
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
E204
E
L
R
E
A
R
I
E
I
A
K
F
S
V
K
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
K138
R
S
R
K
R
L
Q
K
E
M
E
R
H
Q
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
6.6
0
0
0
N.A.
0
73.3
13.3
6.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
13.3
26.6
26.6
26.6
N.A.
26.6
73.3
13.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
0
7
44
0
19
7
7
25
0
38
0
13
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
7
0
0
0
7
0
7
0
% D
% Glu:
19
0
13
7
0
7
13
13
7
7
13
0
7
7
0
% E
% Phe:
0
19
0
0
19
0
0
0
0
0
0
7
0
0
0
% F
% Gly:
0
0
7
0
0
0
7
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
19
7
7
0
0
% H
% Ile:
0
0
0
38
13
0
7
7
13
0
0
19
0
0
7
% I
% Lys:
7
7
0
13
0
13
0
13
7
0
19
7
19
38
19
% K
% Leu:
13
38
0
25
0
19
0
19
44
0
13
0
19
0
19
% L
% Met:
0
0
7
7
0
0
0
0
0
7
0
0
32
0
0
% M
% Asn:
7
0
0
0
0
32
0
0
0
0
0
7
0
0
0
% N
% Pro:
0
0
0
0
7
7
0
0
7
38
0
7
0
19
0
% P
% Gln:
7
0
0
0
0
0
7
0
7
7
0
0
7
7
0
% Q
% Arg:
50
0
13
0
13
19
0
0
13
13
38
7
0
7
44
% R
% Ser:
0
19
7
0
0
0
0
38
0
0
0
0
13
0
7
% S
% Thr:
0
0
0
0
7
7
0
0
0
7
0
0
0
0
7
% T
% Val:
0
0
0
7
0
0
13
0
0
0
0
0
0
7
0
% V
% Trp:
0
0
38
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
7
19
0
0
0
38
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _